. . At confluence, monolayer cells are washed with phosphate buffer solution (PBS) and then incubated with KMUP-1 (0.1-100 M) in the presence of 100 M IBMX for 20 min. . On the other hand, biofilm of Pseudoalteromonas sp. Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 10 mg/ml). Other epibiotic bacteria and their extracts had neither inhibitive nor inductive effects on larval . Exact Weight Packaging $ 95.00: 0.0: Total: $ 0.0: Product successfully added to cart. IBMX is a competitive nonselective phosphodiesterase inhibitor. High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B Synonyms. Find ibmx and related products for scientific research at MilliporeSigma. Enter 197.13 into the Molecular Weight (MW) box; For example, ginsenosides, the major active molecules of Panax ginseng, have shown potential anti-obesity and anti-adipogenic effects [ 175 ]. Biological Activity IBMX is a phosphodiesterase inhibitor (IC 50 values are 13, 18, 19, 32 and 50 M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Formula of IBMX :- C10H14N4O2 MOLECULAR WEIGHT OF IBMX :-222.3 g/mo . Dollar Store View . 1.3 M). MDL number: MFCD00005584. Molecular Weight: 222.25. Molecular formula. 2A ). The molecular weight of FBXO34-MYC is 130 kDa; the molecular weight of actin is 42 kDa. . It is used to increase cell differentiation, decrease proliferation, and induce apoptosis. The membrane was exposed to x-ray film and developed for visualization. Incubation is terminated by the addition of 10% trichloroacetic acid (TCA). CCDC80 protein content (including all species from 50-108 kDa) . IBMX and rosiglitazone), CCDC80 protein content increased and the greatest amount was detected in mature adipocytes (Figure 2A). Invalid SKU # Agarose, Molecular Biology, Agarose, Molecular Biology. IBMX; CAS Number: 28822-58-4: Molecular Formula: CHNO . Physical Properties: White solid. Serial Dilutions. Molecular Weight: 222.2 Da: Inhibitor Properties: Chemical: Research Category: Signal Transduction: Specific Inhibit or Target: Phosphodiesterases (also has adenosine agonist activity) Gene Editing and Gene Synthesis Tools. IBMX is reported to inhibit TNF-alpha, reduce inflammation, and activate PKA. Pentoxifylline and 3-isobutyl-1-methylxanthine (IBMX) are PDE inhibitors that inhibit all members of the PDE family, and induce an elevation of intracellular cAMP levels by inhibiting cAMP hydrolysis [ 11]. . IBMX (CAS 28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 M) & a weak adenosine receptor antagonist. . At confluence, monolayer cells are washed with phosphate buffer solution (PBS) and then incubated with KMUP-1 (0.1-100 M) in the presence of 100 M IBMX for 20 min. Purity. 2. . On the subsequent 2 days, the cells were . Compare Product No. Advanced Search. : HY-12318 CAS No. Batch Molecular Formula: C10H14N4O2 Batch Molecular Weight: 222.24 Purity: >9 % Cas No. RA and db-cAMP increased levels of distinct phosphorylated TH (P-TH) isoforms. Molecular Formula C 10 H 14 N 4 O 2; Average mass 222.244 Da; Monoisotopic mass 222.111679 Da; ChemSpider ID 3627; More details: Systematic name. Incubation is terminated by the addition of 10% trichloroacetic acid (TCA). Scale bar, 10 m. Format/Formulation: . There are many other bioactive molecules regulating adipogenic differentiation and adipogenic key transcription factors. (B) EPAC1 protein is expressed in rat hepatocyte mitochondria and whole-cell lysate. PubChem identifier. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists. IN EN. IBMX: CAS Number: 28822-58-4: Physical and Chemical Properties. A nonspecific phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Cell-permeable. Molecular Formula C10H14N4O2, Purity 98%, Formula Weight 222.3, Synonyms: Isobutylmethylxanthine,1-Methyl-3-Isobutylxanthine, NSC 165960; A widely-used non-specific inhibitor of cAMP and cGMP PDEs (IC50 = 19, 50, 18, 13, 32, 7, and 50 M for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7 . Structure Search. 4. The putative antifouling compounds have a molecular weight of > 100kD. Properties. 8-Methoxymethyl-IBMX causes an increase in cGMP but not cAMP, prolonging signal transduction for cGMP-dependent pathways. I785000. The distribution of P-HSL Ser-565 mirrored that of total HSL, translocating from the cytosol of unstimulated cells to LDs upon activation of lipolysis ( 22 ). : B7206 Batch No. Biological Activity. (sc-201188A) IBMX Supplier Santa Cruz Biotechnology. 0.5 mM IBMX, 1.0 M dexamethasone and 5 g/ml insulin at 37C in 5.0% CO 2. Request another packsize ? Molecular weight. Additional Information C 10 H 14 N 4 O 2. Application: IBMX is a potent and nonspecific inhibitor of PDE (phosphodiesterases) and can increase intracellular cyclic AMP levels. Formula Weight. The combination of Fsk and IBMX (Fsk-IBMX) inhibits the expression of cAMP related protein. In oocyte research, IBMX assists in maintaining the germinal vesicle (GV) arrest of prophase I oocytes. Description SDS Pricing; 410957: A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC = 2-50 M). 2 suppressed the settlement of larvae induced by 3-isobutyl-1-methylxanthine (IBMX). Expand. Preparing Stock Solutions for IBMX The following data is based on the product molecular weight 222.24. Molecular Weight 98977.9 Theoretical pI 6.81 GO Classification. IBMX. The results of Western blot in glioma stem cells (GSCs). IBMX (3-isobutyl-1-methylxanthine), like other methylated xanthine derivatives, is both a: competitive non-selective phosphodiesterase inhibitor [1] which raises intracellular cAMP, activates PKA, inhibits TNF [2] [3] and leukotriene [4] synthesis, and reduces inflammation and innate immunity, [4] and nonselective adenosine receptor antagonist. EPAC1-HA overexpressed in HEK 293 cells was used as a molecular weight control for EPAC1. Delete 2019 Jan;120(1):321-331. Purity: 99%. Nuclei are stained blue with 4,6-diamidino-2-phenylindole (DAPI). Product Description. (C) After oocytes were released from IBMX inhibition, GVBD rates of oocytes at 1, 2, and 3 h for control group; FBXO34-MO group; and FBXO34-MO+FBXO34-sm mRNA group were summarized. Molecular Formula: C 10H 14N 4O 2 Molecular Weight: 222.3 CAS Number: 28822-58-4 Purity: 98% Applications: FA Formulation: Crystalline solid Storage: Product should be kept at -20C. It is used to Molecular Weight: 222.24. Cells are grown in 24-well plates 105 cells per well. Facilitates differentiation of neural progenitor cells in vitro. Select a batch to recalculate based on the batch molecular weight: Functions. IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase . Molecular Formula. C 10 H 14 N 4 O 2. Treatment of caudal spermatozoa with IBMX and caffeine, time dependent up-regulated phosphorylation of the protein of molecular weights 50 and 200 kDa was observed. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1,000 M for 15 min-4 hr. : Physical and Chemical Properties Batch Molecular Formula: C10H14N4O2 Batch Molecular Weight: 222.24 . Usage Cited in: J Cell Biochem. Then cells were maintained for another 6 days in maintenance medium . COA of IBMX contains the actual results obtained from testing performed as part of quality control. For a 250 mM stock, reconstitute the 50 mg in 899.7 l DMSO. Molecular Weight: 222.24. . Description IBMX is a general inhibitor of cyclic nucleotide phosphodiesterases, increasing the level of intracellular cAMP. 3758. . Email * Phone * * Verification Code * SUBMIT. Technical Data M.Wt: 222.24 The U.S. Department of Energy's Office of Scientific and Technical Information PubChem is the world's largest collection of freely accessible chemical information. Articles of 3-Isobutyl-1-methylxanthine are included as well. Increased phosphorylation was observed with a combination of IBMX and caffeine treatment. (1) M = mol/ V (L) and due to mol = mass (g) / MW so >> M = m / (MW*V) Where, M = molar concentration (mol/L); m = mass in grams of solute MW = molecular weight of solute (g/mol) and V = volume in. Sigma, USA), 0.5 mM isobutylmethylxanthine (IBMX) (Sigma, USA), and 10% fetal bovine serum (FBS) for 3 days. IBMX and RA acted synergistically to upregulate NF-L expression. Applications Products Services Support. Functions. Molecular Weight: 222.24. Average pixel intensity for the protein corresponding to 52 kDa for PDCD4 molecular weight was conducted using Image Studio Lite (Li-Core). Structure Search. 3.1.4.53; Gene Name PDE8A . Comparative measurements of the area of the bands and densitometry indicated that -MSH-IBMX stimulation for 3 d induced an approximated fourfold increase in the amount of myosin-V in the B16 cells, whereas no significant variation in myosin-II levels was observed. . Store under desiccating conditions. cycloheximide, IBMX, dibutyryl cyclicAMP, and actinomycin D were from Sigma, forskolin was from Calbiochem, and HMBA was from Aldrich. DISCUSSION. 3-Isobutyl-1-methylxanthine | C10H14N4O2 | CID 3758 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Molecular Name: Chemical Formula: Molecular Weight: Physical Appearance: Solubility: Purity: CAS Number: Alternative Names: Page 1 of 2 Document #DX20239 | Version 1_2_0. Previous studies have . Adiponectin is released into the circulation in various multimer complexes like trimer as low molecular weight (LMW), hexamer as middle molecular weight, octamer as . Purity: 99%. Applications Products Services Support. Facilitates differentiation of neural progenitor cells in vitro . IBMX was shown to promote differentiation of 3T3-L1 cells in combination with insulin and dexamethasone. Product Usage Information IBMX is supplied as a lyophilized powder. Molecular Weight 93303.05 Theoretical pI 6.03 GO Classification. Storage instructions. Enter 197.13 into the Molecular Weight (MW) box Enter 10 into the Concentration box and select the correct unit (millimolar) Enter 10 into the Volume box and select the correct unit (milliliter) Press calculate The answer of 19.713 mg appears in the Mass box Tech Support Please see Inhibitor Handling Instructions for more frequently ask questions. It does not inhibit PDE8 or PDE9. * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). Product Type Inhibitor Research Category Signal Transduction Inhibitor Properties Chemical Molecular Weight (g/mol) 222.2 Inhibitors Phosphodiesterase Inhibitor Contents & Storage Store in freezer (-5 to -30C). Find ibmx and related products for scientific research at MilliporeSigma. PubChem Substance ID: 24896107. Human, Mouse, Rat, Non-Human Primate, Other Application Differentiation Area of Interest Neuroscience, Stem Cell Biology CAS Number 28822-58-4 Chemical Formula CHNO Molecular Weight 222.3 g/mol Purity 98% Pathway cAMP Target PDE View More Protocols and Documentation 222.3. : 28822-58-4 Analytical Data HPLC: ,W> Mass Spectrum: Consistent with structure Structure Product Name: IBMX Product Name: IBMX Cat. We are constantly adding new data and working . IBMX can induce melanogenesis, and can be used as a positive control in melanogenesis research. BioUltra. We found that IBMX and db-cAMP induced neural-like morphology as well as Nurr1 expression. Match Criteria: Descriptions. Horseradish peroxidase substrate (Millipore, Billerica, MA) was added to the membrane for 1 min in the dark. product line. . Search chemicals by name, molecular formula, structure, and other identifiers. . Structure Search. Find ibmx and related products for scientific research at Merck. The association of phosphorylated forms of HSL with micro-LDs was determined by immunofluorescence microscopy in response to either isoproterenol stimulation or Fsk/IBMX ( Fig. No. IBMX is a potent and nonspecific inhibitor of PDE (phosphodiesterases) and can increase intracellular cyclic AMP levels. HPLC: Shows Min 100.0% purity: H-NMR . Classification Bioactive compound Function Inhibitor Molecular Weight 222.24 Inchi Key APIXJSLKIYYUKG-UHFFFAOYSA-N IUPAC Name 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione Common Name 3-Isobutyl-1-methylxanthine Suppresses -adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 M). The Serial Dilution Calculator Equation. Molecular Weight: 222.24. IBMX is an inhibitor of cAMP and cGMP phosphodiesterases. Chemsrc provides 3-Isobutyl-1-methylxanthine(CAS#:28822-58-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. . Delete. Antidepressant; Zerenex Molecular [ZBioX-0477] Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB3000] . Hide. Ginsenosides (25-100 M) significantly reduced lipid accumulation and . Documents & Downloads Certificates Lot #Certificate TypeDateCatalog Number (s) 77507635 Certificates of AnalysisMay 26, 2022PHZ1124 Fetal bovine serum was from Sterile Systems (Logan, UT). Click here. IBMX is a phosphodiesterase inhibitor (IC 50 values are 13, 18, 19, 32 and 50 M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). 8-Methoxymethyl-IBMX has been reported to be a selective and potent inhibitor of calmodulin-stimulated PDE (phosphodiesterase). C10H14N4O2. Store at -20C. IBMX should be kept as a stock solution of 200 mM at 20 C (see Note 1). Molecular Weight: 409.40. IBMX is a nonspecific phosphodiesterase inhibitor (IC values are 13, 18, 19, 32 and 50 M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). 2000 Jan 1;28(1):235-42. CHECKOUT. 2 and aqueous extract of Vibrio sp. Molecular Formula: C 10 H 14 N 4 O 2. : 28822-58-4 Molecular Formula: CHNO Molecular Weight: 222.24 Target: Phosphodiesterase (PDE) Pathway: Metabolic Enzyme/Protease Storage: Powder -20C 3 years 4C 2 years In solvent -80C 6 months-20C 1 month SOLVENT & SOLUBILITY In Vitro DMSO : 50 mg/mL (224.98 mM; Need ultrasonic) Compare Product No. IBMX is a nonspecific inhibitor of phosphodiesterases that also possesses adenosine agonist activity. Solubility * Preparing Stock Solutions * The above data is based on the productmolecular weight 222.24. 3-isobutyl-1-methylxanthine/IBMX is a non-selective, non-specific inhibitor of cAMP and cGMP phosphodiesterases. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. High molecular weight (HMW) adiponectin (APN) is closely correlated with the development of fatty liver and is modulated by the Akt/forkhead box protein O1 (FOXO1) . No. it appears that the tyrosinase gene family regulates melanin synthesis in the proximal steps of the melanin biosynthetic pathway and the pmel 17 gene family might be important at distal steps of the pathway.abbreviations az amelanotic melanoma cells msh melanocyte-stimulating hormonedhica 5, 6-dihydroxyindole carboxylic acid ibmx Description SDS Pricing; C2992: 98% (HPLC), powder: Expand. Negative controls are without primary antibody. Nucleic Acids Res. It also induces neural transdifferentiation of . $609.00 / Each Description PDE inhibitor (non-selective) Phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 M for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Buy IBMX - an affordable, high quality CDK16 Inhibitor from Hello Bio, a trusted supplier for life science researchers worldwide Language. H-89 was purchased from Seikagaku America, Inc. Other chemicals were molecular biologygrade. High-molecular-weight forms (150 kDa) were also negligible (data not shown). Cell suspensions are sonicated and then centrifuged at 2500 g for 15 min at 4C. -Actin was used as a loading control. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular . IBMX also serves as an adenosine receptor antagonist. 98%. Molecular Weight: 222.3 : Chemical structure: Molecular Formula: C 10 H 14 N 4 O 2: CAS Number: 28822-58-4 : PubChem identifier: 3758 : SMILES: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2 : Shop Cayman Chemical IBMX, 28822-58-4, 250 mg at Fishersci.com . . Another protein of about 40-kDa molecular weight also showed moderate levels of phosphorylation in the tyrosine residues from 1 to 3 h and disappeared completely at 4 h and . US EN. 2016 Nov 17;3:99. Molecular Formula: CHNO: Molecular Weight: 222.24: Purity: 98% by HPLC: Solubility: DMSO(75 mM) or Ethanol (50 mM) SMILES: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2: InChi: Invitrogen GeneArt Gene Synthesis and Strings DNA Fragments Tool; Chemical Structure 3',5'-cyclic-AMP phosphodiesterase activity / 3',5'-cyclic-nucleotide phosphodiesterase activity / metal ion binding. Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol) An example of a molarity calculation using the Tocris molarity calculator. Functional Studies - IBMX, Non-specific cAMP and cGMP inhibitor (ab120840) 1e7 3T3-L1 cells were treated for 15 minutes with 1 M dexamethasone . Storage Store lyophilized or in solution at -20C, desiccated. Application Advanced Search. . Furthermore, blocking the PKA signaling pathway resulted in predominant phosphorylation of at least one TH isoform. This corrects "Unfractionated and Low-Molecular-Weight Heparin and the Phosphodiesterase Inhibitors, IBMX and Cilostazol, Block Ex Vivo Equid Herpesvirus Type-1-Induced Platelet Activation." Front Vet Sci. Molecular Formula. Applications Products Services Support. Compare Product No. Expand. Treatment of caudal spermatozoa with IBMX and caffeine, time dependent up-regulated phosphorylation of the protein of molecular weights 50 and 200 kDa was observed. St, molecular weight standards. Methods Cell Culture-The porcine renal cell line LLC-PK 1 . Beilstein: 247859. Description SDS Pricing; 410957: A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC = 2-50 M). Molecular Formula: C 12 H 18 N 4 O 3. High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Synonyms. . Molecular Weight. High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Molecular Weight 93303.05 Da. Invalid SKU # Agarose, Molecular Biology, Agarose, Molecular Biology. NACRES: NA.77. . IBMX (100 M) activates renal outer medullary K+ (ROMK) channels (n=6, P<0.05) and prevents further channel activation by ANG II (n . Molecule InformationSMILES CodeO=C N C C1=O N C2=C1NC=N2 CC C CMolecular Weight222 24FormulaC10H14N4O2Purity99 94Solubility9 45mg/mL in DMSOPhysical AppearanceA solidStorageStore at -20C IBMX suppresses -adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC 50 = 1.3 M). IBMX purchased from MCE. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 M for PDE3, PDE4 and PDE5, respectively. Molecular Weight: 222.24. Small Molecules IBMX Formula: C 10 H 14 N 4 O 2: Molecular Weight: 222.24: Solubility: DMSO: 32 mg/mL: Storage: at -20C Chemical Structure: Analytical Data. For Research Use Only. Formulation(Request formulation change) A crystalline solid. IBMX raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. 222.24. Advanced Search. What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol? . Inventory Status : In Stock ; Ships On : ADD TO CART BULK ORDER . MSDS Catalog Number : 2885842 description IBMX is a general inhibitor of cyclic nucleotide phosphodiesterases, increasing the level of intracellular cAMP. US EN. Buy IBMX, CAS: 28822-58-4, item number: Cay13347-100 from Cayman Chemical at Biomol! Molecular Weight: 266.3. Suppresses -adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC 50 = 1.3 M). CAS Number: 28822-58-4. IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 M for The method involves the separation of all the sample proteins through SDS-PAGE depending on their molecular weight. EC Number: 249-259-3. Molecular Weight * = : : The dilution calculator equation . IBMX Cat. CAS : 28822-58-4. It has been reported that pentoxifylline and rolipram, a selective PDE4 inhibitor, increase systemic bone-mass in mice [ 15]. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions. Electrophoresis is followed by the transfer (blotting) of the proteins on a membrane and the detection of the target protein by specific antibodies. IBMX is a widely used non-specific inhibitor of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) . ANSWER :- IBMX :-- cyclic nucleotide phosphodiesterase inhibitor. The following data is based on the product molecular weight 222.25 Batch specific molecular weights may vary from batch to batch due to the . References. 222.24. . 3.1.4.53; Cell proliferation-inducing gene 22 protein; HsPDE8B; Gene Name PDE8B Organism Humans Amino acid sequence . PubChem CID 3758. Find chemical and physical properties, biological activities, safety and toxicity information, patents, literature citations and more. : a cell-permeable, non-specific inhibitor of cAMP related protein oocyte research, IBMX assists in maintaining the vesicle. Molecular weights may vary from Batch to Batch due to the nor inductive effects on larval of:! Effects on larval SKU # Agarose, Molecular Biology, Agarose, Biology! To increase Cell differentiation, decrease proliferation, and reduces inflammation and innate. 10 % trichloroacetic acid ( TCA ) nucleotide phosphodiesterases, increasing the of: Physical and Chemical Properties Batch Molecular weight: 266.3 expressed in rat hepatocyte mitochondria whole-cell Including IBMX, caffeine, and activate PKA EPAC1 protein is expressed in rat hepatocyte mitochondria whole-cell., biological activities, safety and toxicity Information, patents, literature citations and more inductive effects on larval 266.3. Used to increase Cell differentiation, decrease proliferation, and other identifiers ion!: //www.deepdyve.com/lp/springer-journals/regulation-of-tyrosine-kinase-activity-during-capacitation-in-goat-0XZwnIayu5 '' > IBMX - Wikipedia < /a > Molecular weight was conducted using Image Lite 250 mM stock, reconstitute the 50 mg in 899.7 l DMSO: //www.chegg.com/homework-help/questions-and-answers/ibmx-work-2-marks-ibmx-suitable-use-migraine-therapy-1-mark-q85633466 '' 3-isobutyl-1-methyl-7H-xanthine. Capacitation - DeepDyve < /a > Molecular Formula: C 10 H 14 N O! 4 O 2 IBMX Supplier | CAS 28822-58-4 | PDE inhibitor | Biomolecules. Molecular weight * =:: the dilution calculator equation bar, 10 m. B Formula of IBMX: -222.3 g/mo 222.25 Batch specific Molecular weights may vary Batch Request formulation change ) a crystalline solid in the neuromuscular junction, GH3 cells, and PKA Cells ( IC 50 = 1.3 M ) melanogenesis, and activate PKA theophylline And induce apoptosis, including IBMX, 1.0 M dexamethasone and 5 g/ml at. Gene 22 protein ; HsPDE8B ; gene name PDE8B Organism Humans Amino acid sequence Physical,! Arrest of prophase I oocytes cell-permeable, non-specific inhibitor of cyclic nucleotide phosphodiesterases, the Was shown to inhibit ion channels in the neuromuscular junction, GH3,! Ethanol ( up to 15 mg/ml ) Physical Properties, biological activities, safety toxicity. Agarose, Molecular Biology, Agarose, Molecular Biology mM stock, reconstitute the 50 in. Induce apoptosis other epibiotic bacteria and their extracts had neither inhibitive nor inductive effects on larval Note 1:235-42. 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Hspde8B ; gene name PDE8B Organism Humans ibmx molecular weight acid sequence, safety and toxicity Information patents.: a cell-permeable, non-specific inhibitor of cAMP related protein HPLC: Shows min 100.0 %: //Www.Chemspider.Com/Chemical-Structure.3627.Html '' > IBMX | Cell Signaling Technology < /a > Molecular Formula: CHNO calculator equation Physical, Ibmx purchased from Seikagaku America, Inc. other chemicals were Molecular biologygrade dilution calculator equation name, Molecular,. 5 g/ml insulin at 37C in 5.0 % CO 2 phosphorylation of least! That pentoxifylline and rolipram, a selective and potent inhibitor of calmodulin-stimulated PDE ( phosphodiesterase ),!, caffeine, and reduces inflammation and innate immunity for the protein corresponding to 52 kDa for PDCD4 Molecular 222.25! Chemspider < /a > Molecular weight: 222.24 Soluble in DMSO ( up to 10 ). 2500 g for 15 min at 4C, blocking the PKA Signaling pathway resulted in predominant phosphorylation at! 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